Tonic water!! that's what i keep hearing about....it has the quinine that everyone says is needed to ward of malaria...i'd say just drink that during the entire trip (if you can find them) and use the deet sprays! Malaria is a bigger problem in the tropics than it is in locations like South Africa...but it's not non-existent either.
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The drink gains its name from the medicinal effects of this bitter flavoring. The quinine was added to the drink as a prophylactic against malaria, since it was originally intended for consumption in tropical areas of South Asia and Africa where that disease is endemic.
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I'd check the visa requirements for south africa and verify whether a yellow fever shot is needed. we needed one to get into Ghana and i thought i'd heard that africa as a whole requires proof of immunization against yellow fever.