It will snow... get your holdover times down pat. You will lose a pack at FL350... You will have to the gate trying to feed you 75 checked bags, 10 heavies, and 25 gate-checked with full fuel & full pax for a flight from RDU-IAH with 200NM headwinds... You will have some funky ACARS indication that you have never seen before... ever... You will get a hold on a radial not near any point that's not standard... and you won't get any crew meals or coffee since the G8XXX FA forgot to tell you the coffee maker is broken... and this will all happen on your Fed Ride...
At least... that's what they tell me...
Good luck man!
Bob