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I know of an airline flying CRJ-70's into Key West and normally they're blocked at 65 seats or so because of weight/performance restrictions.
At least so a little bird tells me.
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I'm assuming you're talking about ASA?
The 65 seat restriction sounds very true!
This is what I can confirm, directly from Delta's website:
Domestic U.S. only:
Customers traveling to or from Key West, Florida are limited to 1 checked bag.
http://www.delta.com/travel/plan/bag...ex.jsp#Checked
So, yes, they definetly have some weight and balance issues to address flying out of EYW.