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If you take in less calories than you burn, you will lose weight. If you take in more calories than you burn, you will gain weight.
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More getting to the brass-tacks.
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That's the problem. The high fructose corn syrup is part of the problem, but people consuming too much of it is the main problem.
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Every food is caloric or fattening in some way or another. The person's self control (or not) is the bottom line.